TISSUE and GENETIC ENGINEERING

AIM

Doku mühendisliği, vücuttaki hastalıklı veya yaralı doku ve organları yenilemeyi veya onarmayı amaçlayan bir alandır. Doku mühendisliği, biyoloji, kimya, malzeme bilimi, mühendislik, immünoloji ve transplantasyon gibi birçok farklı bilimi kapsar. Ders, doku büyümesi ve gelişimi ile doku ve organların tasarlanması için gerekli araç ve teorik bilgilerin genel bir anlayışını sağlar. Öğrencilere yönelik öğrenme yöntemi ve sömestir projesi, öğrencilere doku kavramlarını, ilkelerini ve uygulamalarını tanıtmak için öğretim aracı olarak kullanılacaktır.

CONTENT

This course contains; Introductory Lecture,Introduction to Tissue Engineering ,How Genetic Engineering serves to Tissue Engineering ,Stem Cell Tissue Engineering ,Polymeric Scaffolds for Tissue Engineering Applications ,Fabrication Methods of Tissue Engineering Scaffolds,3D Organ Printing and Cell Encapsulation,Basics in Immunology and Immune Host Response to Biomaterials,Extracellular Matrix: Structure Function, and Application to Tissue Engineering,Microvascular Imaging Methods for Tissue Engineering,In Vitro & In Vivo Testing,Standards and Regulations in Tissue Engineering Applications: ISO, FDA etc.,Project Presentations,Selected Topics on Tissue Engineering.

1. 1

   Describe the tissue engineering as a prominent approach composed of different disciplines

   Taught by: Discussion Method, Case Study Method, Self Study Method, Computer-Internet Supported Instruction, Cooperative Learning, Lecture Method · Assessed by: Traditional Written Exam, Project Task

2. 2

   Define the different strategies and approaches in tissue engineering

   Taught by: Discussion Method, Self Study Method, Project Based Learning Model, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

3. 3

   Analyze, evaluate, describe and compare different experimental techniques in tissue engineering

   Taught by: Discussion Method, Self Study Method, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

4. 4

   Understand the experimental design of a tissue engineering study

   Taught by: Discussion Method, Computer-Internet Supported Instruction, Inquiry-Based Learning, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

5. 5

   Get the ability to combine their personal knowledge in biology, material science, engineering and medicine to understand and address the challenges in tissue engineering

   Taught by: Discussion Method, Micro Teaching Technique, Project Based Learning Model, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

6. 6

   Describe the national and universal standards for tissue engineering preclinic and clinic applications

   Taught by: Discussion Method, Micro Teaching Technique, Project Based Learning Model, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

WEEKLY PLAN

1. WEEK 1

   Introductory Lecture

2. WEEK 2

   Introduction to Tissue Engineering

3. WEEK 3

   How Genetic Engineering serves to Tissue Engineering

4. WEEK 4

   Stem Cell Tissue Engineering

5. WEEK 5

   Polymeric Scaffolds for Tissue Engineering Applications

6. WEEK 6

   Fabrication Methods of Tissue Engineering Scaffolds

7. WEEK 7

   3D Organ Printing and Cell Encapsulation

8. WEEK 8

   Basics in Immunology and Immune Host Response to Biomaterials

9. WEEK 9

   Extracellular Matrix: Structure Function, and Application to Tissue Engineering

10. WEEK 10

    Microvascular Imaging Methods for Tissue Engineering

11. WEEK 11

    In Vitro & In Vivo Testing

12. WEEK 12

    Standards and Regulations in Tissue Engineering Applications: ISO, FDA etc.

13. WEEK 13

    Project Presentations

14. WEEK 14

    Selected Topics on Tissue Engineering

ASSESSMENT

• Rate of Midterm Exam to Success30%
• Rate of Final Exam to Success70%

WORKLOAD

READING

• (1) Migliaresi, Claudio, and Antonella Motta. Scaffolds for tissue engineering: Biological design, materials, and fabrication. Jenny Stanford Publishing, 2014. (2) Birla, Ravi. Introduction to tissue engineering: applications and challenges. John Wiley & Sons, 2014. (3) Bronzino, Joseph D., and Donald R. Peterson. Tissue engineering and artificial organs. CRC press, 2016

TEACHING STAFF

• Assoc.Prof. Özge ŞENSOYCOORDINATOR
• Assoc.Prof. Özge ŞENSOY
• Prof.Dr. Esra ÇAĞAVİ
• Assist.Prof. Elif HOCAOĞLU
• Prof.Dr. Yasemin YÜKSEL DURMAZ