PROTEIN: STRUCTURE and FUNCTION

AIM

The aim of the course is to understand the 3D structure of proteins and make connection between the structure and the function of proteins. In addition, novel proteins can be designed with tailored functions.

CONTENT

This course contains; Basic Structural Principles,Folding and Flexibility,DNA Structure,Structure, Function and Engineering,The mechanism of DNA recognition in prokaryotes and eukaryotes ,Enzyme Catalysis,Membrane Proteins,Signal Transduction,Fibrous Proteins,The mechanism of recognition of foreign molecules by immune system,The Structure of Spherical Viruses,The principles of prediction, Engineering and Design of Protein Structures,Determination of Protein Structures,Special Topics.

1. 1

   Capable of building the relation between protein structure and function

   Taught by: Discussion Method, Problem Solving Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Homework, Project Task

2. 2

   Proteins can be designed with novel functions.

   Taught by: Discussion Method, Problem Solving Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Cooperative Learning, Lecture Method · Assessed by: Traditional Written Exam, Homework, Project Task

3. 3

   The impact of environment on the enzyme kinetics can be interpreted.

   Taught by: Discussion Method, Question - Answer Technique, Brainstorming Technique, Reverse Brainstorming Technique · Assessed by: Traditional Written Exam, Homework, Project Task

4. 4

   Capable of interpretation of the results obtained from molecular dynamics simulations in terms of protein structure-function relationship.

   Taught by: Question - Answer Technique, Brainstorming Technique, Reverse Brainstorming Technique · Assessed by: Traditional Written Exam, Homework, Project Task

WEEKLY PLAN

1. WEEK 1

   Basic Structural Principles

2. WEEK 2

   Folding and Flexibility

3. WEEK 3

   DNA Structure

4. WEEK 4

   Structure, Function and Engineering

5. WEEK 5

   The mechanism of DNA recognition in prokaryotes and eukaryotes

6. WEEK 6

   Enzyme Catalysis

7. WEEK 7

   Membrane Proteins

8. WEEK 8

   Signal Transduction

9. WEEK 9

   Fibrous Proteins

10. WEEK 10

    The mechanism of recognition of foreign molecules by immune system

11. WEEK 11

    The Structure of Spherical Viruses

12. WEEK 12

    The principles of prediction, Engineering and Design of Protein Structures

13. WEEK 13

    Determination of Protein Structures

14. WEEK 14

    Special Topics

ASSESSMENT

• Rate of Midterm Exam to Success30%
• Rate of Final Exam to Success70%

WORKLOAD

READING

• Introduction to Protein Structure, 2 nd Edition, Carl Brendon and John Tooze

TEACHING STAFF

• Assoc.Prof. Özge ŞENSOYCOORDINATOR
• Assoc.Prof. Özge ŞENSOY