BIOCHEMISTRY

AIM

It is aimed to strengthen the basic biochemistry knowledge of 2 nd year students in this course, which is going to be taken in Spring. We will start the course by focusing on the structure and properties of water which is one of the important molecules that form organisms. The acid/base character of amino acids along with the structure, function, and purification methods of proteins will also be studied. This will be followed by considering the structure and function of enzyme as well as their regulation. Subsequently, the mechanism of a enzyme-ligand complex will be focused on the basis of allostery and cooperatively phenomena. Finally, some selected hot topics in the field of biochemistry will be discussed interactively with the students.

CONTENT

This course contains; Molecular Interactions in a Biological Context Introduction to Biochemistry,Overview of Energy and Metabolism,Carbohydrates,Glycogen Metabolism,Glycolysis,Citric Acid Cycle,Electron Transfer Chain and Oxidative Phosphorylation,Enzyme Reactions,Lipids,Lipid Metabolism,Amino Acids,Protein Structure,Fibrous Proteins,Globular Proteins.

1. 1

   Explains the basic structures, biochemical properties, and biological functions of carbohydrates, lipids, amino acids, and proteins.

2. 2

   Defines and relates the major metabolic pathways, including glycolysis, glycogen metabolism, the pentose phosphate pathway, the citric acid cycle, oxidative phosphorylation, gluconeogenesis, and basic lipid metabolism.

3. 3

   Interprets the fundamental biochemical principles related to enzymes, protein structure–function relationships, and buffer systems.

4. 4

   Relates cellular energy production, biomolecular transformation, and metabolic regulation to biomedical engineering applications.

5. 5

   Evaluates and interprets data obtained from basic biochemistry laboratory applications such as spectrophotometric measurement, glucose assay, total lipid analysis, and serum protein determination, report.

WEEKLY PLAN

1. WEEK 1

   Molecular Interactions in a Biological Context Introduction to Biochemistry

   Preparation: Going through course materials

2. WEEK 2

   Overview of Energy and Metabolism

   Preparation: Going through course materials

3. WEEK 3

   Carbohydrates

   Preparation: Going through course materials

4. WEEK 4

   Glycogen Metabolism

   Preparation: Going through course materials

5. WEEK 5

   Glycolysis

   Preparation: Going through course materials

6. WEEK 6

   Citric Acid Cycle

   Preparation: Going through course materials

7. WEEK 7

   Electron Transfer Chain and Oxidative Phosphorylation

   Preparation: Going through course materials

8. WEEK 8

   Enzyme Reactions

   Preparation: Going through course materials

9. WEEK 9

   Lipids

   Preparation: Going through course materials

10. WEEK 10

    Lipid Metabolism

    Preparation: Going through course materials

11. WEEK 11

    Amino Acids

    Preparation: Going through course materials

12. WEEK 12

    Protein Structure

    Preparation: Going through course materials

13. WEEK 13

    Fibrous Proteins

    Preparation: Going through course materials

14. WEEK 14

    Globular Proteins

    Preparation: Going through course materials

ASSESSMENT

• Rate of Midterm Exam to Success30%
• Rate of Final Exam to Success70%

WORKLOAD

READING

• Principles of Biochemistry - 5 th edition - Laurence A. Moran & Robert A. Horton 2. Biochemistry - 8 th edition- Mary K. Campbell & Shawn O. Farrell.

TEACHING STAFF

• Prof.Dr. Sultan Sibel ERDEMCOORDINATOR
• Res.Assist. Birgün ÖZÇOLAK ASLAN