NANOMEDICINE and NANOMATERIALS

AIM

This course will go through nanomaterials for nanomedicine. Specifically it focuses on understanding the central role of polymeric nanotherapeutics in the development of new therapeutic and diagnostic tools that can be used for detection, imaging, and treatment of different life-threatening diseases. The course will discuss formulation of nanostructures and their application in targeted delivery of therapeutic and imaging agents. The course will discuss specific example of “smart nanomaterials, self assembled structures, multifunctional nanoparticles as well as magnetic nanoparticles and quantum dots. Further, the course will discuss hydrogels, shape memory polymers for implants, nanomaterials for biosensors, nanocarrier for gene delivery and carbon nanomaterials for various biomedical application. The class will rely on interactive discussion supported by multiple examples from relevant literature.

CONTENT

This course contains; Introduction to Nanomadicine and Nanomaterials,Early Example of Polymer Drug Conjugates,Overview of Synthetic Strategies of Polymer Therapeutics,Characterization of Polymers Therapeütics,Self Assembled Structures-Structural Requirements,Self-Assemble Structure : Their Fate in the Body,"Smart" Nanomaterials,Nanocarriers for Gene Delivery,Hydrogels,Quantum Dots for Cancer Targeting,Shape Memory Polymers,Multifunctional Nanoparticles for Theranostics,Carbon Nanomaterials,Hot Topics:Presentations.

1. 1

   Distinguish the structure-properties relationships of synthetic and natural macromolecules

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

2. 2

   Recognize nanomaterials for nanomedicine

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

3. 3

   Apply knowledge of material science to the design and evaluation of new drug delivery systems

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

4. 4

   Assess the influence of advanced drug delivery technologies on optimization of drug therapy

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

5. 5

   Interpret the interactions of polymers with the biological environment

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

6. 6

   Interpret influence of the biological fate of polymeric carriers on controlled drug delivery

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

7. 7

   Identify important factors responsible for the successful design of targetable drug carriers

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

8. 8

   Compare the different drug delivery system

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

9. 9

   Summarize various technologies utilized for feedback-controlled drug delivery

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

10. 10

    Summarize the basic constructs used in stimuli-sensitive polymeric drug delivery systems

    Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

11. 11

    Recognize the major components of non-viral gene and oligonucleotide delivery systems

    Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

12. 12

    Design nanomedicine/nanoterpeutics/theranostics for specific disease

    Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Project Task

WEEKLY PLAN

1. WEEK 1

   Introduction to Nanomadicine and Nanomaterials

   Preparation: Going through course materials and reading recommended articles

2. WEEK 2

   Early Example of Polymer Drug Conjugates

   Preparation: Going through course materials and reeding recommended articles

3. WEEK 3

   Overview of Synthetic Strategies of Polymer Therapeutics

   Preparation: Going through course materials and reeding recommended articles

4. WEEK 4

   Characterization of Polymers Therapeütics

   Preparation: Going through course materials and reeding recommended articles

5. WEEK 5

   Self Assembled Structures-Structural Requirements

   Preparation: Going through course materials and reeding recommended articles

6. WEEK 6

   Self-Assemble Structure : Their Fate in the Body

   Preparation: Going through course materials and reeding recommended articles

7. WEEK 7

   "Smart" Nanomaterials

   Preparation: Going through course materials and reeding recommended articles

8. WEEK 8

   Nanocarriers for Gene Delivery

   Preparation: Going through course materials and reeding recommended articles

9. WEEK 9

   Hydrogels

   Preparation: Going through course materials and reeding recommended articles

10. WEEK 10

    Quantum Dots for Cancer Targeting

    Preparation: Going through course materials and reeding recommended articles

11. WEEK 11

    Shape Memory Polymers

    Preparation: Going through course materials and reeding recommended articles

12. WEEK 12

    Multifunctional Nanoparticles for Theranostics

    Preparation: Going through course materials and reeding recommended articles

13. WEEK 13

    Carbon Nanomaterials

    Preparation: Going through course materials and reeding recommended articles

14. WEEK 14

    Hot Topics:Presentations

    Preparation: Search about hot topic and preparation of a presentation

ASSESSMENT

• Rate of Midterm Exam to Success50%
• Rate of Final Exam to Success50%

WORKLOAD

READING

• Course materials as “ppt” files
• Recent publications or reviews of related topics

TEACHING STAFF

• Prof.Dr. Yasemin YÜKSEL DURMAZCOORDINATOR
• Prof.Dr. Yasemin YÜKSEL DURMAZ