NANOMEDICINE and NANOMATERIALS

AIM

This course will go through nanomaterials for nanomedicine. Specifically it focuses on understanding the central role of polymeric nanotherapeutics in the development of new therapeutic and diagnostic tools that can be used for detection, imaging, and treatment of different life-threatening diseases. The course will discuss formulation of nanostructures and their application in targeted delivery of therapeutic and imaging agents. The course will discuss specific example of “smart nanomaterials, self assembled structures, multifunctional nanoparticles as well as magnetic nanoparticles and quantum dots. Further, the course will discuss hydrogels, shape memory polymers for implants, nanomaterials for biosensors, nanocarrier for gene delivery and carbon nanomaterials for various biomedical application. The class will rely on interactive discussion supported by multiple examples from relevant literature.

CONTENT

This course contains; Introduction to Nanomadicine and Nanomaterials,Natural Polymers for Nanomaterials,Natural Polymers for Nanomaterials,Self Assembled Structures,Self Assembled Structures, “Smart” Nanomaterials (stimuli sensitive system),Multifunctional Nanoparticles for Theranostics,Quantum Dots for Cancer Targeting,Hydrogels,Nanocarrier for Gene Delivery,Shape Memory Polymers,Nanomaterials for Biosensor applications,Carbon Nanomaterials,Project Presentation.

1. 1

   Recognize nanomaterials for nanomedicine

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

2. 2

   Distinguish the structure-properties relationships of synthetic and natural macromolecules

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

3. 3

   pply knowledge of material science to the design and evaluation of new drug delivery systems

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

4. 4

   Assess the influence of advanced drug delivery technologies on optimization of drug therapy

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

5. 5

   Understand the interactions of polymers with the biological environment

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

6. 6

   Interpret influence of the biological fate of polymeric carriers on controlled drug delivery

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

7. 7

   Identify important factors responsible for the successful design of targetable drug carriers

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

8. 8

   Analyse the requirement of different drug delivery system

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

9. 9

   Compare various technologies utilized for feedback-controlled drug delivery

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

10. 10

    Summarize the basic constructs used in stimuli-sensitive polymeric drug delivery systems

    Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

11. 11

    Identify the major components of non-viral gene and oligonucleotide delivery systems

    Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

12. 12

    Design and formulate nanomedicine/nanoterpeutics/theranostics for specific disease

    Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Micro Teaching Technique, Brainstorming Technique, Lecture Method · Assessed by: Homework, Project Task

WEEKLY PLAN

1. WEEK 1

   Introduction to Nanomadicine and Nanomaterials

   Preparation: Going through course materials and reading recommended articles

2. WEEK 2

   Natural Polymers for Nanomaterials

   Preparation: Going through course materials and reading recommended articles

3. WEEK 3

   Natural Polymers for Nanomaterials

   Preparation: Going through course materials and reading recommended articles

4. WEEK 4

   Self Assembled Structures

   Preparation: Going through course materials and reading recommended articles

5. WEEK 5

   Self Assembled Structures

   Preparation: Going through course materials and reading recommended articles

6. WEEK 6

   “Smart” Nanomaterials (stimuli sensitive system)

   Preparation: Going through course materials and reading recommended articles

7. WEEK 7

   Multifunctional Nanoparticles for Theranostics

   Preparation: Going through course materials and reading recommended articles

8. WEEK 8

   Quantum Dots for Cancer Targeting

   Preparation: Going through course materials and reading recommended articles

9. WEEK 9

   Hydrogels

   Preparation: Going through course materials and reading recommended articles

10. WEEK 10

    Nanocarrier for Gene Delivery

    Preparation: Going through course materials and reading recommended articles

11. WEEK 11

    Shape Memory Polymers

    Preparation: Going through course materials and reading recommended articles

12. WEEK 12

    Nanomaterials for Biosensor applications

    Preparation: Going through course materials and reading recommended articles

13. WEEK 13

    Carbon Nanomaterials

    Preparation: Going through course materials and reading recommended articles

14. WEEK 14

    Project Presentation

    Preparation: Going through course materials and reading recommended articles

ASSESSMENT

• Rate of Midterm Exam to Success50%
• Rate of Final Exam to Success50%

WORKLOAD

READING

• Lecturer will provide course materials as “ppt” files
• Recent publications or reviews of related topics

TEACHING STAFF

• Prof.Dr. Yasemin YÜKSEL DURMAZCOORDINATOR
• Prof.Dr. Yasemin YÜKSEL DURMAZ