TISSUE ENGINEERING

AIM

Tissue engineering is a field that aims to regenerate or repair diseased or injured tissues and organs in the body. Tissue engineering encompasses several different sciences such as biology, chemistry, material science, engineering, immunology and transplantation. The course provides a general understanding of tissue growth and development as well as the tools and theoretical information necessary to design tissues and organs; and will use student-directed learning as the teaching tool to introduce students to the concepts, principles, and applications of tissue engineering.

CONTENT

This course contains; Introductory Lesson: Course Content Introduction,Introduction to Tissue Engineering,How Genetic Engineering Supports Tissue Engineering,Stem Cell Tissue Engineering,Polymeric Scaffolds for Tissue Engineering Applications,Tissue Engineering Scaffold Production Methods,3-Dimensional Organ Printing and Cell Encapsulation,Fundamentals of Immunology and Immune Host Response to Biomaterials,Extracellular Matrix: Structure Function and Application to Tissue Engineering,Microvascular Imaging Methods for Tissue Engineering,In Vitro & In Vivo Test Methods,Standards and Regulations in Tissue Engineering Applications: ISO, FDA etc.,Term Project Presentations,Applied Topics in Tissue Engineering.

1. 1

   1. Define tissue engineering as an important approach consisting of different disciplines.

   Taught by: Discussion Method, Case Study Method, Self Study Method, Computer-Internet Supported Instruction, Cooperative Learning, Lecture Method · Assessed by: Traditional Written Exam, Project Task

2. 2

   2. Compare the different strategies and approaches in tissue engineering.

   Taught by: Discussion Method, Self Study Method, Project Based Learning Model, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

3. 3

   3. Analyze different experimental techniques in tissue engineering.

   Taught by: Discussion Method, Self Study Method, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

4. 4

   4. Evaluates the experimental setup of a tissue engineering research.

   Taught by: Discussion Method, Computer-Internet Supported Instruction, Inquiry-Based Learning, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

5. 5

   5. Combines the personal knowledge in biology, materials science, engineering and medicine to understand and solve challenges in tissue engineering

   Taught by: Discussion Method, Micro Teaching Technique, Project Based Learning Model, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

6. 6

   6. Define national and universal standards for tissue engineering preclinical and clinical applications.

   Taught by: Discussion Method, Micro Teaching Technique, Project Based Learning Model, Cooperative Learning · Assessed by: Traditional Written Exam, Project Task

WEEKLY PLAN

1. WEEK 1

   Introductory Lesson: Course Content Introduction

   Preparation: Going through course materials and reading recommended articles

2. WEEK 2

   Introduction to Tissue Engineering

   Preparation: Going through course materials and reading recommended articles

3. WEEK 3

   How Genetic Engineering Supports Tissue Engineering

   Preparation: Going through course materials and reading recommended articles

4. WEEK 4

   Stem Cell Tissue Engineering

   Preparation: Going through course materials and reading recommended articles

5. WEEK 5

   Polymeric Scaffolds for Tissue Engineering Applications

   Preparation: Going through course materials and reading recommended articles

6. WEEK 6

   Tissue Engineering Scaffold Production Methods

   Preparation: Going through course materials and reading recommended articles

7. WEEK 7

   3-Dimensional Organ Printing and Cell Encapsulation

   Preparation: Going through course materials and reading recommended articles

8. WEEK 8

   Fundamentals of Immunology and Immune Host Response to Biomaterials

   Preparation: Going through course materials and reading recommended articles

9. WEEK 9

   Extracellular Matrix: Structure Function and Application to Tissue Engineering

   Preparation: Going through course materials and reading recommended articles

10. WEEK 10

    Microvascular Imaging Methods for Tissue Engineering

    Preparation: Going through course materials and reading recommended articles

11. WEEK 11

    In Vitro & In Vivo Test Methods

    Preparation: Going through course materials and reading recommended articles

12. WEEK 12

    Standards and Regulations in Tissue Engineering Applications: ISO, FDA etc.

    Preparation: Going through course materials and reading recommended articles

13. WEEK 13

    Term Project Presentations

    Preparation: Going through course materials and reading recommended articles

14. WEEK 14

    Applied Topics in Tissue Engineering

    Preparation: Going through course materials and reading recommended articles

ASSESSMENT

• Rate of Midterm Exam to Success50%
• Rate of Final Exam to Success50%

WORKLOAD

READING

• (1) Migliaresi, Claudio, and Antonella Motta. Scaffolds for tissue engineering: Biological design, materials, and fabrication. Jenny Stanford Publishing, 2014. (2) Birla, Ravi. Introduction to tissue engineering: applications and challenges. John Wiley & Sons, 2014. (3) Bronzino, Joseph D., and Donald R. Peterson. Tissue engineering and artificial organs. CRC press, 2016

TEACHING STAFF

• Assoc.Prof. Özge ŞENSOYCOORDINATOR
• Assoc.Prof. Özge ŞENSOY