BIOSENSORS : CONCEPTS and STRATEGIES

AIM

Underlying engineering principles used to detect small molecules, DNA, proteins, and cells in the context of applications in diagnostic testing, pharmaceutical research, and environmental monitoring. Biosensor approaches including electrochemistry, fluorescence, acoustics, and optics; aspects of selective surface chemistry including methods for biomolecule attachment to transducer surfaces; characterization of bisensor performance; blood glucose detection; fluorescent DNA microarrays; label-free biochips; bead-based assay methods. Case studies and analysis of commercial biosensor.

CONTENT

This course contains; Introduction to biosensors and their applications,The design and capabilities of bioselective layers,Biomolecular structure and function,Mass transport and biosensing in a flow stream,Biosensor figures of merit for comparison of approaches,Labels and Assays,Introduction to Electrochemistry,Electrochemical Biosensors,Impedance based biosensors,Acoustic Biosensors,Surface plasmon resonance biosensors,Optical Biosensors,Flourescence based biosensors,Raman and surface-enhanced Raman Spectroscopy.

1. 1

   Describes the working principles of biosensor groups

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

2. 2

   Compares the Biosensors

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

3. 3

   Designs biosensors for application

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

4. 4

   Evaluates the interaction of biochemical functionality with biosensor transducers

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

5. 5

   Exemplifies biosensor applications in diagnostic testing, life sciences research studies, and environmental monitoring

   Taught by: Discussion Method, Self Study Method, Question - Answer Technique, Lecture Method · Assessed by: Traditional Written Exam, Project Task

WEEKLY PLAN

1. WEEK 1

   Introduction to biosensors and their applications

   Preparation: Going through course materials

2. WEEK 2

   The design and capabilities of bioselective layers

   Preparation: Going through course materials

3. WEEK 3

   Biomolecular structure and function

   Preparation: Going through course materials

4. WEEK 4

   Mass transport and biosensing in a flow stream

   Preparation: Going through course materials

5. WEEK 5

   Biosensor figures of merit for comparison of approaches

   Preparation: Going through course materials

6. WEEK 6

   Labels and Assays

   Preparation: Going through course materials

7. WEEK 7

   Introduction to Electrochemistry

   Preparation: Going through course materials

8. WEEK 8

   Electrochemical Biosensors

   Preparation: Going through course materials

9. WEEK 9

   Impedance based biosensors

   Preparation: Going through course materials

10. WEEK 10

    Acoustic Biosensors

    Preparation: Going through course materials

11. WEEK 11

    Surface plasmon resonance biosensors

    Preparation: Going through course materials

12. WEEK 12

    Optical Biosensors

    Preparation: Going through course materials

13. WEEK 13

    Flourescence based biosensors

    Preparation: Going through course materials

14. WEEK 14

    Raman and surface-enhanced Raman Spectroscopy

    Preparation: Going through course materials

ASSESSMENT

• Rate of Midterm Exam to Success50%
• Rate of Final Exam to Success50%

WORKLOAD

READING

• Gennady Evtugyn, "Biosensors: Essentials", Springer, 2014 Jeong-Yeol Yoon, "Introduction to Biosensors", Springer, 2016

TEACHING STAFF

• Assoc.Prof. Hasan KURTCOORDINATOR
• Assoc.Prof. Hasan KURT