CELL and TISSUE ENGINEERING

AIM

The aim of this course is to examine cell, materials, and biochemical factors that play a vital role in regeneration of functional tissues.

CONTENT

This course contains; Introduction to cell and tissue engineering,Tissue types and extracellular matrixes,Cell-cell and cell-matrix interactions,Cell-biomaterials interactions,Mechanical properties of tissues and biomaterials,Stem cells in tissue engineering,Drug and gene delivery,Unit cell processes,Tissue engineering in skin regeneration,Tissue engineering in bone regeneration,Tissue engineering in nerve regeneration,Tissue engineering in cardiovascular regeneration,Tissue engineering in musculoskeletal regeneration,Ethical issues and regulatory perspectives.

1. 1

   Describes the physiological properties of tissues in the human body.

   Taught by: Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam

2. 2

   It analyzes the cell's interaction with surrounding tissues.

   Taught by: Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam

3. 3

   Summarizes the differentiation mechanisms of stem cells and their applications in bioengineering.

   Taught by: Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam

4. 4

   It analyzes the responses of cells to changes in the mechanical properties of the surrounding tissue.

   Taught by: Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Quiz

5. 5

   Analyzes tissue regeneration mechanisms in various tissues.

   Taught by: Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Homework, Quiz

6. 6

   Defines the design parameters of biomaterials used in tissue regeneration.

   Taught by: Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Quiz

7. 7

   Comments on ethical issues related to tissue engineering.

   Taught by: Self Study Method, Question - Answer Technique, Brainstorming Technique, Lecture Method · Assessed by: Traditional Written Exam, Homework, Quiz

WEEKLY PLAN

1. WEEK 1

   Introduction to cell and tissue engineering

2. WEEK 2

   Tissue types and extracellular matrixes

3. WEEK 3

   Cell-cell and cell-matrix interactions

4. WEEK 4

   Cell-biomaterials interactions

5. WEEK 5

   Mechanical properties of tissues and biomaterials

6. WEEK 6

   Stem cells in tissue engineering

7. WEEK 7

   Drug and gene delivery

8. WEEK 8

   Unit cell processes

9. WEEK 9

   Tissue engineering in skin regeneration

10. WEEK 10

    Tissue engineering in bone regeneration

11. WEEK 11

    Tissue engineering in nerve regeneration

12. WEEK 12

    Tissue engineering in cardiovascular regeneration

13. WEEK 13

    Tissue engineering in musculoskeletal regeneration

14. WEEK 14

    Ethical issues and regulatory perspectives

ASSESSMENT

• Rate of Midterm Exam to Success50%
• Rate of Final Exam to Success50%

WORKLOAD

READING

• 1. Presentation of the lecture notes 2. “Tissue Engineering” B.O. Palsson and S.N. Bhatia, Pearson, 2004 3. “Principles of Tissue Engineering” R. Lanza, R. Langer, J. Vacanti, Academic Press, 2013 4. Recent journal articles about tissue engineering topics
• 1- “Tissue Engineering” B.O. Palsson and S.N. Bhatia, Pearson, 2004 2- “Principles of Tissue Engineering” R. Lanza, R. Langer, J. Vacanti, Academic Press, 2013

TEACHING STAFF

• Assoc.Prof. Özge ŞENSOYCOORDINATOR
• Assoc.Prof. Özge ŞENSOY